Remembering an older conversation about how to run games for 1 GM and 1 player, here is an article talking about how Trail of Cthulhu was adapted into the 1-GM-1-player game Cthulhu Confidential. I especially like what they did with health to prevent player deaths (and the inherent TPK it entails) outlined in paragraphs 12 through 14.
http://site.pelgranepress.com/index.php/see-p-xx-whats-changed-in-gumshoe-one-2-one/